Antioxidant and Anti-inflammatory Benefit of Agrimony
Agrimony (Agrimonia eupatoria) has been reported to posses strong anti-oxidative and anti-inflammatory activity. In a study done in the Department of Biochemistry, Molecular Medicine and Nutrigenomics, Medical University Varna, Bulgaria, the effects of agrimony tea consumption was examined in humans.
Results have shown that there was a significant elevation of plasma total antioxidant capacity and a significant lowering of the interleukin 6 levels at the end of the intervention. It was also observed that agrimony tea improved lipid profile as estimated by increased high density lipoprotein (HDL) cholesterol. The results presented in this first human intervention study with agrimony tea indicate that the plant has potential in improving markers of lipid metabolism, oxidative status and inflammation in healthy adults. http://www.ncbi.nlm.nih.gov/pubmed/23078582
Inhibition of hepatitis B virus by an aqueous extract of Agrimonia eupatoria L.
The inhibitory activity of the aqueous extract of agrimony (Agrimonia Eupatoria L.) was studied in the Cell Biology Laboratory, Korea Research Institute of Bioscience and Biotechnology. Results had shown that the inhibitory effect on HBsAg secretion has the greatest effect on the extract prepared at 60 degrees C. The inhibitory activity of Agrimonia eupatoria extracts on HBsAg secretion varied over the growing season and was the highest at mid-July. These results suggest that some plants of the genus Agrimonia contain potential antiviral activity against HBV. http://www.ncbi.nlm.nih.gov/pubmed/16041735
Agrimonia eupatoria protects against chronic ethanol-induced liver injury in rats.
A study conducted in School of Pharmacy, Sungkyunkwan University, South Korea. reported the hepatoprotective effects of Agrimonia eupatoria water extract against chronic ethanol-induced liver injury in rats. The study was done to rats fed with Lieber-DeCarli liquid diet for 8 weeks, then orally treated with agrimony extract at 10, 30, 100, and 300 mg/kg/day. Our results suggest that agrimonia eupatoria water extract attenuates and ameliorates chronic ethanol-induced liver injury, and that protection is likely due to the suppression of oxidative stress and TLR-mediated inflammatory signaling. http://www.ncbi.nlm.nih.gov/pubmed/22525864
Anti-inflammatory and anti-allergic effects of Agrimonia pilosa Ledeb extract on murine cell lines and OVA-induced airway inflammation.
The Journal of Ethnopharmacology, issue March 2012 reported a study done in the Department of Biotechnology, College of Biomedical & Health Science, Korea on Agrimonia pilosa Ledeb and its anti-inflammatory and anti-allergic effects in in vitro cell lines and in vivo mouse model and the involved molecular mechanisms. Using Raw 264.7 murine macrophages the effects of methanol extract of Agrimonia pilosa in lipopolysaccharide (LPS)-induced production of inflammatory mediators were measured. To investigate the anti-asthmatic effect of Agrimonia pilosa extract in vivo, airway inflammation in ovalbumin (OVA)-induced mouse model was used.
Results have shown that the molecular mechanisms leading to agrimonia's potent anti-inflammatory and anti-allergic effects might be through regulation of TRIF-dependent and Syk-PLCγ/AKT signaling pathways, suggesting that Agrimonia pilosa may provide a valuable therapeutic strategy in treating various inflammatory diseases including asthma. http://www.ncbi.nlm.nih.gov/pubmed/22289347
Effect of neuroprotective flavonoids of Agrimonia eupatoria on glutamate-induced oxidative injury to HT22 hippocampal cells
. Lee KY, Hwang L, Jeong EJ, Kim SH, Kim YC, Sung SH. Source College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul, Korea.
In a study done in the College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Korea, showed that methanolic extract of Agrimonia eupatoria significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. A new flavonoid, characterized as kaempferol 3-O-beta-D-(2''-O-acetyl-6''-(E)-p-coumaroyl)-glucopyranoside (2''-acetyl-tiliroside (1), was isolated from the methanolic extract of Agrimonia eupatoria stems together with nine known flavonoids. Agrimonia compounds showed a neuroprotective effect on glutamate-induced toxicity in HT22 cells. http://www.ncbi.nlm.nih.gov/pubmed/20699556
Antibacterial and free radical scavenging activity of the seeds of Agrimonia eupatoria.
In a study done in Phytopharmaceutical Research Laboratory, School of Pharmacy, The Robert Gordon University, Schoolhill, Aberdeen, Scotland, UK, the n-Hexane, dichloromethane and methanol extracts of the seeds of Agrimonia eupatoria have been assessed for antibacterial and free radical scavenging activity. http://www.ncbi.nlm.nih.gov/pubmed/12628408